University of Illinois Properties to Prioritize in An Optimization Program Questions

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Part 1.

Choose three properties that you would prioritize if you were running a lead optimization program and explain the primary reasons for you choices. ( 1 paragraph 10-11 sentences)

Read the referenced article and provide your comments as the contents applies to clinical trial design.http://ascopubs.org/doi/full/10.1200/jco.2010.31.7024 ( 1 paragraph 10-11 sentences)

Part 2

1.) Using the referenced file, if putting together a clinical research study budget is nothing more involved than creating a MS Excel spreadsheet, why do we find researchers, authors, and even consultants dedicated to the subject?- 1 page

2.) What are the differences between descriptive, comparative, and inferential statistics?

sorry for the delay I know have question 3:  In 2005, 72,007 men and 69,398 women were diagnosed with colorectal cancer. Assume that you are the statistician designing a clinical trial for a new drug that purports to cure this disease. Using the referenced website, what would your recommended sample size be, given a 5% margin of error and a 95% confidence level?http://www.raosoft.com/samplesize.htmlThe DeGoey et al., paper describes numerous clinically effective drugs that have one or more properties “beyond” Lipinski’s Rule of 5.  Is it time to replace Lipinski’s rules with a more current set of rules based on recent experience?  If so, what parameters would these new rules include?  Would they be applied to every program?  Would they be applied at the very beginning of the program? 7-9 SENTENCES

In 2005, 72,007 men and 69,398 women were diagnosed with colorectal cancer. Assume that you are the statistician designing a clinical trial for a new drug that purports to cure this disease. Using the referenced website, what would your recommended sample size be, given a 5% margin of error and a 95% confidence level?http://www.raosoft.com/samplesize.html

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